The Chicago Symphony, Detroit Symphony, National Symphony, U.S. Air Force Band, U.S. Army Band, The Singers, Manhattan Concert Chorale, and Gregg Smith Singers all have Luther graduates among their members. Luther alumni have won national and regional levels of the Metropolitan Opera National Council Auditions and are performing at opera companies across the country, including the Metropolitan Opera, Lyric Opera of Chicago, Houston Grand Opera, as well as in major international opera houses. The number of Luther alumni presently performing with professional ensembles confirms the department's success in preparing solo performers.

Many Luther alumni have entered graduate degree programs to prepare for careers in performance or college teaching. Recent graduates have attended the University of Indiana, University of Cincinnati-College Conservatory of Music, University of Illinois at Urbana-Champaign, University of North Texas, University of Minnesota, University of Missouri, University of Michigan, University of Texas at Austin, State University of New York-Stony Brook, Florida State University, Yale University, Rice University, Eastman School of Music, Manhattan School of Music, Mannes College of Music, and the Juilliard School of Music.

The Music Education minor is another option for music majors, and Luther graduates have succeeded consistently in securing elementary and secondary teaching positions in the region, the nation, and internationally.

The college continues to train many musicians for full-time or part-time church music and music ministry work. Recent graduates are serving congregations throughout the Twin Cities, the entire Midwest region, and nationally.